Figure 5.

Function of miR-8 in the process of ecdysone-induced fly size determination. Ecdysone signaling continuously influences the miR-8 and, concomitantly, insulin signaling throughout the third instar larval period. When altered levels of miR-8 induced by changes in ecdysone signaling are sustained throughout this period, the effects of miR-8 alteration accumulate, leading to a significant difference in the final body size. In model figures, the increase of body size during the third instar larval period is expressed as the area under the curve (AUC).