Table 3.
Summary of statistical analysis of plasma PF-04457845 exposure (food effect study)
| 90% confidence interval | |||
|---|---|---|---|
| Parameter (units) | Ratio (%)* | Lower | Upper |
| Food effect (comparison: tablet fed vs. tablet fasted [8 mg PF-04457845]) | |||
| AUC(0,∞) (ng ml−1 h) | 104 | 98 | 111 |
| AUC(0,tlast) (ng ml−1 h) | 107 | 97 | 111 |
| Cmax (ng ml−1) | 106 | 90 | 124 |
| Relative bioavailability (comparison: tablet vs. solution [8 mg PF-04457845]) | |||
| AUC(0,∞) (ng ml−1 h) | 103 | 97 | 110 |
| AUC(0,tlast) (ng ml−1 h) | 102 | 96 | 110 |
| Cmax (ng ml−1) | 65 | 55 | 76 |
*
Ratio of adjusted geometric means. AUC(0,tlast) = area under the plasma concentration–time profile from time zero to the time of the last quantifiable concentration, AUC(0,∞) = area under the plasma concentration–time profile from time zero to infinity, Cmax = maximum observed concentration within the dosing interval.