Table 4.
Absolute risk of an injurious fall per day for the use of SSRIs and hypnotics or sedatives
| Absolute risk of an injurious fall | No SSRIs | 0.25 DDD SSRIs | 0.50 DDD SSRIs | 1.00 DDD SSRIs |
|---|---|---|---|---|
| No co-prescribed hypnotics or sedatives | ||||
| p(f,80) (95% CI) | 0.09 (0.06, 0.14) | 0.12 (0.09, 0.18) | 0.16 (0.11, 0.24) | 0.28 (0.17, 0.45) |
| p(m,80) (95% CI) | 0.13 (0.07, 0.17) | 0.17 (0.10, 0.22) | 0.22 (0.13, 0.29) | 0.38 (0.20, 0.55) |
| p(f,85) (95% CI) | 0.12 (0.08, 0.17) | 0.15 (0.11, 0.22) | 0.20 (0.14, 0.29) | 0.35 (0.22, 0.56) |
| p(m,85) (95% CI) | 0.16 (0.09, 0.22) | 0.21 (0.12, 0.28) | 0.28 (0.15, 0.38) | 0.48 (0.24, 0.72) |
| Increase in absolute risk of an injurious fall* | ref | 31% | 73% | 198% |
| Absolute risk of an injurious fall | No SSRIs | 0.25 DDD SSRIs | 0.50 DDD SSRIs | 1.00 DDD SSRIs |
|---|---|---|---|---|
| 0.50 DDD hypnotics or sedatives | ||||
| p(f,80) (95% CI) | 0.15 (0.09, 0.25) | 0.20 (0.12, 0.33) | 0.26 (0.15, 0.43) | 0.44 (0.25, 0.80) |
| p(m,80) (95% CI) | 0.20 (0.10, 0.30) | 0.27 (0.14, 0.39) | 0.35 (0.18,0.51) | 0.61 (0.29, 0.96) |
| p(f,85) (95% CI) | 0.19 (0.11, 0.31) | 0.25 (0.15, 0.40) | 0.32 (0.20, 0.53) | 0.56 (0.31, 0.99) |
| p(m,85) (95% CI) | 0.26 (0.13, 0.38) | 0.34 (0.17, 0.50) | 0.44 (0.22, 0.66) | 0.76 (0.35, 1.23) |
| Increase in absolute risk of an injurious fall* | 59% | 109% | 174% | 373% |
| Absolute risk of an injurious fall | No SSRIs | 0.25 DDD SSRIs | 0.50 DDD SSRIs | 1.00 DDD SSRIs |
|---|---|---|---|---|
| 1.00 DDD hypnotics or sedatives | ||||
| p(f,80) (95% CI) | 0.24 (0.10, 0.58) | 0.31 (0.13, 0.76) | 0.41 (0.17, 1.00) | 0.71 (0.28, 1.80) |
| p(m,80) (95% CI) | 0.33 (0.12, 0.68) | 0.43 (0.15, 0.89) | 0.56 (0.20, 1.17) | 0.97 (0.33, 2.11) |
| p(f,85) (95% CI) | 0.30 (0.12, 0.72) | 0.39 (0.16, 0.94) | 0.51 (0.21, 1.23) | 0.88 (0.35, 2.22) |
| p(m,85) (95% CI) | 0.41 (0.14, 0.86) | 0.53 (0.19, 1.13) | 0.70 (0.25, 1.49) | 1.21 (0.41, 2.69) |
| Increase in absolute risk of an injurious fall* | 152% | 232% | 336% | 651% |
DDD, Defined Daily Dose; p(f,80), absolute risk of an injurious fall in percentages per day for females aged 80 years; p(m,80), absolute risk of an injurious fall in percentages per day for males aged 80 years; p(f,85), absolute risk of an injurious fall in percentages per day for females aged 85 years; p(m,85), absolute risk of an injurious fall in percentages per day for males aged 85 years. hypnotics or sedatives (N05C); SSRIs (N05AB).
*
The increase in absolute risk of an injurious fall is relative to a person of any age taking no SSRIs and no sedatives or hypnotics.