Table 1.

Summary of iPSC lines generated

	Patient			Disease					iPSC
	Code	Sex	Agea	Age onset	Family history	Mutation	Initial symptomsb	LDopa response	# of Lines	Clones selected	Karyotype	Transgene silencingc	Pluripotency markersc	In vitro differentiationc	Teratoma assayc
CONTROL	SP09	M	66						4	SP09.2	46,XY	Passed	Passed	Passed	N/P
										SP09.4	46,XY	Passed	Passed	Passed	Passed
	SP11	F	48						3	SP11.1	46,XX	Passed	Passed	Passed	Passed
										SP11.4	46,XX	Passed	Passed	Passed	N/P
	SP15	F	47						4	SP15.2	46,XX	Passed	Passed	Passed	Passed
										SP15.3	46,XX	Passed	Passed	Passed	N/P
										SP15.4	47,XX + 20	Passed	Passed	N/P	N/P
	SP17	M	52						3	SP17.1	47,XY + 20	Passed	Passed	Passed	N/P
										SP17.2	46,XY	Passed	Passed	Passed	Passed
										SP17.3	46,XY	Passed	Passed	Failed	N/P
ID-PD	SP01	F	63	58	No	No	T and B	N/A	4	SP01.1	46,XX	Passed	Passed	Passed	Passed
										SP01.4	46,XX	Passed	Passed	Passed	N/P
	SP02	M	55	48	No	No	T	N/A	2	SP02.1	46,XY	Passed	Passed	Passed	Passed
										SP02.2	46,XY	Passed	Passed	Passed	N/P
	SP04	M	46	40	No	No	B	Good	2	SP04.1	46,XY	Passed	Passed	Passed	N/P
										SP04.2	46,XY	Passed	Passed	Passed	Passed
	SP08	F	66	60	No	No	T	Good	4	SP08.1	46,XX	Passed	Passed	Passed	Passed
										SP08.2	46,XX	Passed	Passed	Passed	N/P
										SP08.3	46,XX	Failed	N/P	N/P	N/P
	SP10	M	58	50	No	No	D	Good	2	SP10.1	46,XY	Passed	Passed	Passed	N/P
										SP10.2	46,XY	Passed	Passed	Passed	Passed
	SP14	M	55	51	No	No	B	Good	2	SP14.1	46,XY	Passed	Passed	Passed	Passed
										SP14.2	46,XY	Passed	Passed	Passed	N/P
	SP16	F	51	48	No	No	B	N/A	4	SP16.2	46,XX	Passed	Passed	Passed	Passed
										SP16.3	46,XX	Passed	Passed	Passed	N/P
LRRK2-PD	SP05	M	66	52	Yes	LRRK2	B	Good	2	SP05.1	46,XY	Passed	Passed	Passed	Passed
										SP05.2	46,XY	Passed	Passed	Passed	N/P
	SP06	M	44	33	Yes	LRRK2	T	Good	6	SP06.1	46,XY	Passed	Passed	N/P	N/P
										SP06.2	46,XY	Passed	Passed	Passed	Passed
	SP12	F	63	49	Yes	LRRK2	T	Good	4	SP12.3	46,XX	Passed	Passed	Passed	Passed
										SP12.4	46,XX	Passed	Passed	Passed	N/P
	SP13	F	68	57	Yes	LRRK2	T	Good	4	SP13.2	46,XX	Passed	Passed	Passed	N/P
										SP13.4	46,XX	Passed	Passed	Passed	Passed

N/A, information not available; N/P, test not performed.

^aAge at biopsy.

^bT, tremor; B, bradykinesia; D, foot dystonia.

^cTests performed as exemplified in Fig 1.