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. 2012 May;4(5):412–423. doi: 10.1002/emmm.201200217

Figure 7. Role of endothelial ADAM17 for cytokine secretion in LPS-induced lung inflammation.

Figure 7

Control and Tie2-adam17−/− mice were intranasally treated with LPS or vehicle control (PBS). Data represent means ± SEM (n = 3 per group). Significance was calculated using one-way ANOVA followed by the Newman–Keuls post-test and is indicated by asterisks (*p < 0.05, **p < 0.01, ***p < 0.001). Asterisks without line indicate significance to the appropriate PBS-treated controls.

A-C. After 4 h of challenge, release of IL-6 (A), TNF-α (B) and KC (C) into BAL fluid was determined by ELISA measurement.

D. Control and Tie2-adam17−/− mice were compared for TNF-α-induced lung inflammation. The wet-dry-ratio of lung tissue was determined after 24 h of intranasal TNF-α-challenge.