Table 1.
Mode of inflammatory modulation | Genetic model of AD | Pathological changes observed | References | |||
---|---|---|---|---|---|---|
Amyloid load | Tau pathology | Neuronal degeneration | Microglial “activation” | |||
LPS intracranial | APP/PS1 amyloid | ↓ | ↑ | [5, 7] | ||
LPS intracranial | rTg4510 tau | ↑ | ↑ | [8] | ||
Anti-Aβ immunotherapy | APP amyloid | ↓ | ↑ | [13, 14] | ||
Anti-Aβ immunotherapy | APP/NOS−/− amyloid, tau, neuron loss | ↓ | ↓ | ↓ | ↑ | [17] |
IL-1β overexpression in brain | APP/PS1 amyloid | ↓ | ↑ | [22] | ||
TGFβ overexpression in brain | APP amyloid | ↓ | ↑ | [19] | ||
TNFR1 and R2 deletion | 3Xtg amyloid and tau | ↑ | ↓ | [21] |