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Cellular uptake and DNA platination.(a) Whole-cell Pt accumulation and (b) extent of DNA platination, following incubation with 1.0, 2.5, and 10 μM oxaliplatin (filled bars) or equivalent doses of DACHPt/cl-micelles (open bars) following 24 h exposure in A2780 cells as measured by ICP-MS. Values are mean ± standard deviation (n = 3).
