Table 1.
D
eff
(nm) |
PDIb |
ζ-potential (mV) |
LCc
(%) |
LEd
(%) |
|
---|---|---|---|---|---|
Empty cl-micelles | 170 ± 20 | 0.12 | −38 ± 8 | n.a | n.a |
DACHPt/cl-micelles | 154 ± 10 | 0.10 | −30 ± 5 | 25 | 45 |
aValues determined at pH 7.0, values are mean ± standard deviation.
bPDI: polydispersity index.
cLC: loading capacity (percentage of drug by weight incorporated into drug loaded cl-micelles), R = 0.5.
dLE: loading efficiency (percentage of drug incorporated into cl-micelles for a given amount of drug added to the mixture), R = 0.5.