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Specific Activities for Mutant Proteins
| Enzyme | Specific activity (μmol min−1 mg−1) | Fold decrease in activity |
|---|---|---|
| Wild-type | (3.4 ± 0.1) × 10−2 | |
| H181N | (5.6 ± 0.1) × 10−4 | 61 |
| Y222F | (1.0 ± 0.1) × 10−4 | 340 |
| E224Q | (2.6 ± 0.1) × 10−4 | 130 |
| H225N | (9.5 ± 0.8) × 10−7 | 36,000 |
| Y76F | (2.9 ± 0.3) × 10−4 | 120 |
| H181N/E224Q | (1.4 ± 0.1) × 10−6 | 24,000 |
