Figure 3.

Predicted interactions of the designed mutations in the HIV-1 protease variant Pr3 (A28S/D30F/G48R) with the substrate RT–RH displayed in stereo. In the predicted structure, G48R, forms a salt bridge with Glu at the P3 position in RT-RH, there are improved van der Waals interactions between D30F and Ala at P4 in RT-RH and A28S makes a hydrogen bond with Thr at P2 in RT-RH. RT-RH is shown in green (residues N and C terminal with respect to the scissile bond are colored green and limon green, respectively) and the two monomers are colored magenta and cyan, respectively.