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Selectivity of primary TNAP scaffolds
| Compound ID | PubChem SID |
PubChem CID |
Structure | SDCCG panel (IC50, uM) |
PubChem panel (# of assays) |
|||
|---|---|---|---|---|---|---|---|---|
| TNAP | PLAP | IAP | Active | Total | ||||
| MLS-0010847 | 26514189 | 645853 |  |
0.926 | >100 | >100 | 1 (TNAP) | 234 |
| MLS-0038949 | 26514170 | 2931238 |  |
0.193 | >100 | >100 | 2 (TNAP, CYP2C19) |
214 |
| MLS-0005718 | 843997 | 646303 |  |
0.743 | >100 | 43.5 | 1 (TNAP) | 242 |
| MLS-0039961 | 4257586 | 610864 |  |
4.33 | >100 | >100 | 1 (TNAP) | 213 |
| MLS-0067142 | 4260165 | 2975791 |  |
0.186 | 3.14 | 0.539 | 2 (TNAP, IAP) |
221 |
