Figure 6.

Plots of Cell-free DNA vs ATP_end and vs Ox Phos and vs MES_inh for 131 patients of Cohort 2. Almost all patients are above the reference range of up to 95 μg/l and there is a strong anti-correlation as ATP_end and Ox Phos decrease to the lowest values measured, and these anti-correlations are reflected in the MES_inh plot. For Cell-free DNA we use the SI unit μg/l although the traditional unit of μg/dl (which gives numbers lower by a factor of 10) is still widely used. Note that the scale for ATPend starts at 0.5 fmol/cell rather than at zero; this is because ATPend has a rather sharp minimum value of 0.66 fmol/cell, as already noted in Figure 2.