Figure 1.

Co-application of zinc doesn’t affect hASIC1b currents in hASIC1b transfected CHO cells. A, Representative traces showing pH-6.0 elicited hASIC1b currents with co-application of different concentrations of zinc in CHO cells. Transient inward hASIC1b currents in CHO cells were recorded with drops in pH from 7.4 to 6.0 in whole-cell configurations at –60 mV. The duration of co-application with pH drops is 7 seconds. B & C, Quantification of relative peak current amplitude (B), and sustained-component (C) of pH 6.0-activated currents with co-application of zinc at different concentrations. Each point represents the average responses of five to eight cells. There are no significant differences between each group (p > 0.05, ANOVA). CTRL represents control.