Figure 4.

Zinc inhibition of hASIC1b currents in hASIC1b transfected CHO cells is independent of calcium. A, Original current traces showing inhibitory effect of pre-applied zinc on hASIC1b currents in the presence of 2, 5 and 10 mM Ca²⁺. hASIC currents were activated by a drop in pH from 7.4 to 6.0 at a membrane potential of -60 mV. B, Quantification of relative peak amplitude of zinc inhibition at different concentrations of Ca²⁺. Each point represents the average response of five cells. There are no significant differences between different groups (p > 0.05, ANOVA). CTRL represents control.