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α and γ MSH inhibit systemic inflammatory signalling induced by the NFκB pathway. Human bronchial epithelial cells (HBE) were exposed for 6h to 106cfu.ml-1 of Rhinosyncitial Virus (RSV) or 10μg.ml-1 of Pseudomonas aeruginosa lipopolysaccharide (LPS). α, β, or γ MSH were added at 10μg.ml-1. NFκB activity was measured by luciferase assay. Secreted interleukin 8 (IL8) and eotaxin were measured by ELISA (R&D). (*P<0.05 relative to control; n=4 independent experiments).
