Table 4.
Enriched KEGG pathway of mouse cBIP and sBIP gene classes.
| KEGG pathway ID | Pathway Name | p-value | gene type |
|---|---|---|---|
| mmu03040* | Spliceosome | 3.30E-03 | cBIP |
| mmu04110 | Cell cycle | 3.70E-03 | cBIP |
| mmu04142 | Lysosome | 4.13E-03 | cBIP |
| mmu03018* | RNA degradation | 5.70E-03 | cBIP |
| mmu00970 | Aminoacyl-tRNA biosynthesis | 8.74E-03 | cBIP |
| mmu03020* | RNA polymerase | 8.97E-03 | cBIP |
| mmu00190 | Oxidative phosphorylation | 1.07E-02 | cBIP |
| mmu03440# | Homologous recombination | 1.36E-02 | cBIP |
| mmu00052 | Galactose metabolism | 1.59E-02 | cBIP |
| mmu05012 | Parkinson's disease | 1.98E-02 | cBIP |
| mmu04146 | Peroxisome | 3.03E-02 | cBIP |
| mmu03420# | Nucleotide excision repair | 3.30E-02 | cBIP |
| mmu00240 | Pyrimidine metabolism | 6.22E-03 | sBIP |
| mmu03020* | RNA polymerase | 5.15E-03 | sBIP |
| mmu00062 | Fatty acid elongation in mitochondria | 1.10E-02 | sBIP |
| mmu00903 | Limonene and pinene degradation | 1.40E-02 | sBIP |
| mmu00280 | Valine, leucine and isoleucine degradation | 1.98E-02 | sBIP |
| mmu05340 | Primary immunodeficiency | 4.08E-02 | sBIP |
| mmu00860 | Porphyrin and chlorophyll metabolism | 4.96E-02 | sBIP |
The two catteries of mouse bidirectional genes (cBIP, sBIP) were computed for the KEGG pathway enrichment respectively. cBIP represents the genes regulated by the human-mouse conserved bidirectional promoters, while the sBIP represents the genes in the species-specific bidirectional gene pairs. * Transcription and translation related pathways # DNA repair related pathways