Table 3.
Associations of HCAs, B[a]P, heme iron, nitrite, and nitrate and prostate cancer in African-American men (N=3,903)
| Intake Tertiles | ||||
|---|---|---|---|---|
| Q1 (ref) | Q2 | Q3 | Ptrend | |
| Any prostate cancer (N=541) | ||||
| DiMeIQx | 0.02 | |||
| Cases (median) | 165 (0.04) | 180 (0.32) | 196 (1.47) | |
| HR (95% CI) | 1.00 | 1.15 (0.93–1.42) | 1.30 (1.05–1.61) | |
| MeIQx | 0.22 | |||
| Cases (median) | 189 (1.67) | 168 (7.63) | 184 (22.99) | |
| HR (95% CI) | 1.00 | 0.97 (0.79–1.20) | 1.12 (0.90–1.38) | |
| PhIP | 0.50 | |||
| Cases (median) | 194 (6.20) | 168 (30.76) | 179 (99.27) | |
| HR (95% CI) | 1.00 | 0.87 (0.71–1.08) | 1.03 (0.84–1.26) | |
| B[a]P | 0.66 | |||
| Cases (median) | 192 (0.47) | 179 (3.01) | 170 (19.89) | |
| HR (95% CI) | 1.00 | 0.95 (0.77–1.16) | 0.94 (0.76–1.16) | |
| Heme iron | 0.45 | |||
| Cases (median) | 192 (65.95) | 178 (140.31) | 171 (263.55) | |
| HR (95% CI) | 1.00 | 0.95 (0.77–1.18) | 1.07 (0.86–1.34) | |
| Nitrite | 0.77 | |||
| Cases (median) | 198 (23.67) | 171 (66.19) | 172 (159.76) | |
| HR (95% CI) | 1.00 | 0.91 (0.74–1.13) | 1.01 (0.82–1.25) | |
| Nitrate | 0.37 | |||
| Cases (median) | 175 (51.05) | 198 (155.89) | 168 (336.49) | |
| HR (95% CI) | 1.00 | 1.18 (0.95–1.45) | 1.13 (0.90–1.41) | |
| Advanced prostate cancer (N=47) | ||||
| DiMeIQx | 0.66 | |||
| Cases (median) | 18 (0.04) | 16 (0.32) | 13 (1.47) | |
| HR (95% CI) | 1.00 | 0.91 (0.45–1.83) | 0.84 (0.41–1.74) | |
| MeIQx | 0.52 | |||
| Cases (median) | 22 (1.67) | 11 (7.63) | 14 (22.99) | |
| HR (95% CI) | 1.00 | 0.60 (0.29–1.24) | 0.72 (0.35–1.47) | |
| PhIP | 0.93 | |||
| Cases (median) | 17 (6.20) | 17 (30.76) | 13 (99.27) | |
| HR (95% CI) | 1.00 | 1.18 (0.59–2.39) | 1.02 (0.48–2.14) | |
| B[a]P | 0.23 | |||
| Cases (median) | 18 (0.47) | 18 (3.01) | 11 (19.89) | |
| HR (95% CI) | 1.00 | 1.03 (0.53–2.01) | 0.66 (0.31–1.43) | |
| Heme iron | 0.69 | |||
| Cases (median) | 19 (65.95) | 13 (140.31) | 15 (263.55) | |
| HR (95% CI) | 1.00 | 0.83 (0.39–1.75) | 1.12 (0.53–2.35) | |
| Nitrite | 0.34 | |||
| Cases (median) | 18 (23.67) | 12 (66.18) | 17 (159.76) | |
| HR (95% CI) | 1.00 | 0.83 (0.38–1.80) | 1.31 (0.64–2.65) | |
| Nitrate | 0.25 | |||
| Cases (median) | 18 (51.05) | 12 (155.89) | 17 (336.49) | |
| HR (95% CI) | 1.00 | 0.78 (0.34–1.65) | 1.40 (0.68–2.87) | |
Number of cases (median value for each tertile) and HRs (95% CIs) reported. P-values for trend test.
Models adjusted for age, education, marital status, family history of prostate cancer, history of diabetes, smoking, health status, BME, alcohol, fruit intakes.