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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Methods Mol Biol. 2012;887:135–148. doi: 10.1007/978-1-61779-860-3_13

Figure 1.

Figure 1

The safety incorporation and processing of biologics is accurately monitored in the rat fenestration animal models as shown by the vector transduction efficiency and systemic distribution by bioluminescence. After the surgery on the right side, most of the luciferin signal is restricted to the alveolar bone defect region. However, a significant vector expression can be also noticed in distant organs, with maximum expression at day 14, followed by a decrease in vector expression in the head and neck region over time as well as in the maxillary area. Reproduced with permission from (12).