| Proof-of-concept in a short time frame |
Narrow healing time window |
| Well-contained defects |
Small size, surgical microscopes required; technically challenging |
| No gingival tissue ingrowth |
Rapid repair as kinetic healing model |
| Relatively low cost |
Cannot measure healing of junctional epithelial-connective tissue interface |
| Controllable microflora |
Not a “natural disease” model with microbial influence |
| Known age |
Different anatomical structures compared to humans |
| Known genetic background |
Different histopathologic features |
| Ease of handling and housing |
Different host responses compared with humans |
