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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Mol Immunol. 2012 Jun 7;52(3-4):155–164. doi: 10.1016/j.molimm.2012.05.004

Figure 4. A fast kinetics based serial triggering model.

Figure 4

TCR recognition of an antigenic pMHC leads to CD3 ITAM phosphorylation and signaling. The TCR ligation signal promotes the formation of TCR protein islands/clusters on the T cell membrane. The fast kinetics of TCR-pMHC interaction allows the TCRs in the cluster to serially engage with a small number of antigens on the APC surface and maximize T cell signaling and activation.