Table 3.
Medication and association with HbA1c
| Mean ± SD or n (%) |
Association with HbA1c1) |
||
|---|---|---|---|
| Coefficient | P-value | ||
| Anitdiabetic therapy |
312 (96.6) |
|
0.022 c), 3d) |
| None (n, %) |
12 (3.7) |
|
|
| Only oral (n, %) 2) |
208 (64.4) |
|
|
| Only insulin (n, %) 2) |
26 (8.0) |
|
|
| Combined (insulin and oral) (n, %) 2) |
77 (23.8) |
|
|
| Specific antidiabetic therapies |
|
|
|
| Insulin (n, %) |
103 (31.9) |
|
0.005 b), 3e) |
| Metformin/Biguanid (%) |
254 (78.6) |
|
0.384 b) |
| Sulfonylurea (n, %) |
136 (42.1) |
|
0.764 b) |
| Gliptine (DPP-III) (n, %) |
44 (13.6) |
|
0.425 b) |
| Glitazone (n, %) |
19 (5.9) |
|
0.553 b) |
| Glinide (n, %) |
10 (3.1) |
|
0.160 b) |
| Incretin mimetic (n, %) |
6 (1.9) |
|
0.090 b) 3f) |
| α-Glucosidase inhibitor (n, %) |
4 (1.2) |
|
0.837 b) |
| Any antihypertensive agent (n, %) 2) |
246 (76.2) |
|
0.098 b), 3g) |
| Diuretics (n, %) |
160 (49.5) |
|
0.317 b) |
| Inhibitor of the angiotensin converting enzyme (ACE-I) (n, %) |
156 (48.3) |
|
0.213 b) |
| Beta-blocker (n, %) |
101 (31.3) |
|
0.321 b) |
| Angiotensin II inhibitor (ARB) (n, %) |
70 (21.7) |
|
0.787 b) |
| Calcium antagonists (n, %) |
64 (19.8) |
|
0.135 b) |
| others (n, %) |
4 (1.2) |
|
0.838 b) |
| Any antiplatelet therapy (n, %) 2) |
179 (55.4) |
|
0.700 b) |
| Aspirin (n, %) |
158 (48.9) |
|
0.869 b) |
| Phenprocoumon (n, %) |
21 (6.5) |
|
0.017 b), 3h) |
| Clopidogrel (n, %) |
17 (5.3) |
|
0.505 b) |
| Any lipid-lowering therapy (n, %) 2) |
182 (56.3) |
|
0.005 b), 3i) |
| Any antidepressants (n, %) |
37 (11.5) |
|
0.751 b) |
| Number of drugs total | 4.8 (2.1) | -0.052 | 0.349 a) |
1) a) Associations HbA1c with continuous variables by Pearson correlations, between HbA1c and categorical variables by b) t-tests and c) ANOVA.
2) 1 or more drugs possible.
3) HbA1c (%) mean per category of significant t-test and ANOVA results (p < 0.010): d) Anitdiabetic therapy: none = 7.2, only oral = 7.6, only insulin = 7.8, combined (insulin and oral) = 8.0; e) Insulin: yes = 8.0, no = 7.6; f) Incretin mimetic: yes = 8.6, no = 7.7; g) Any antihypertensive agent: yes = 7.6, no = 8.0; h) Phenprocoumon: yes = 7.4, no = 7.7; i) Any lipid-lowering therapy: yes = 7.5, no = 7.9.