Table 1.
Groups |
1stChallenge* (0 pi) |
2ndChallenge* (84 pi) |
|
---|---|---|---|
Experiment 1 20 pigs |
A |
strain 3262 |
Group A + A (n = 4) |
Homologous challenge: strain 3262 | |||
14 pigs† |
Group A + B (n = 4) |
||
Heterologous challenge: strain 3267 | |||
C1 |
Placebo |
Group C1 + B (n = 2) |
|
6 pigs†† |
naïve controls: strain 3267 |
||
Experiment 211 pigs | B |
strain 3267 |
Group B + B (n = 4) |
Homologous challenge: strain 3267 | |||
8 pigs |
Group B + A (n = 3**) |
||
Heterologous challenge: strain 3262 | |||
C2 |
Placebo | Group C2 + A (n = 3) |
|
3 pigs | naïve controls: strain 3262 |
* Inoculation was performed intranasally (2 mL; 1 mL/nostril) with a dosis of 5 × 105.0 TCID50/mL of the corresponding strain
** One pig died at 17 pi in the first inoculation.
† Six pigs were euthanized; three at 15 pi and three at 35 pi.
†† Four pigs were euthanized: two at 15 pi and two at +35 pi.