Table 1.

Proteins Significantly Different in GHR−/− Compared with Wild-Type (WT) Mice (p < .01)

Protein ID	Isoform Numbers	Fold Difference	Significance Level
APOA4	3	↑ 1.7	F(1,18) = 70.3, p = 1 × 10−7
	4	↑ 1.9	F(1,18) = 19.4, p = .0003
	Total	↑ 1.6	F(1,18) = 88.8, p = 2 × 10−8
RBP-4	1	↑ 1.8	F(1,18) = 18.2, p = .0005
	2	↑ 3.0	F(1,18) = 17.6, p = .001
	3	↑ 4.2	F(1,18) = 15.8, p = .0001
APOE	1	↓ 8.3	F(1,18) = 10.2, p = .005
	3	↓ 2.5	F(1,18) = 46.7, p = 2 × 10−6
	4	↓ 1.7	F(1,18) = 12.9, p = .002
	Total	↓ 1.6	F(1,18) = 19.7, p = .0003
MBP-C	1	↓ 11.5	F(1,18) = 11, p = .004
	2	↓ 11.1	F(1,18) = 8.3, p = .01
HP	1	↓ 2.6	F(1,18) = 4.7, p = .044

Notes: Protein isoform Numbers correspond to those shown in Figure 3. The fold difference was calculated as the ratio of the mean values of GHR−/− mice and WT mice (pooled samples regardless of sex or age). “↑” Means upregulation and “↓” means downregulation. Two-way analysis of variance with repeated measures revealed a significant genotype difference. APOE = apolipoprotein E; HP = haptoglobin; MBP-C = mannose-binding protein-C; RBP-4 = retinol-binding protein-4.