Table 2.

Proteins Significantly Different in Males and Females (p < .05)

Protein ID	Isoform Numbers	Fold Difference	Significance Level
APOE	1	↑ 3.2	F(1,18) = 30, p = 3 × 10−5
RBP-4	2	↓ 2	F(1,18) = 8.7, p = .009
HP	1	↓ 12.5	F(1,18) = 22.2, p = .0002
Albumin	1	↓ 2.7	F(1,18) = 11.1, p = .004
	5	↓ 4	F(1,18) = 15.1, p = .001
HBB	1	↓ 9.1	F(1,18) = 18.2, p = .0005

Notes: Protein isoform numbers correspond to those shown in Figure 3. The fold difference of male vs female was calculated as the mean value of female/mean value of male (pooled samples regardless of genotype or age). “↑” Means upregulation and “↓” means downregulation. Two-way analysis of variance with repeated measures revealed a significant sex difference. APOE = apolipoprotein E; HBB = hemoglobin subunit beta; HP = haptoglobin; RBP-4 = retinol-binding protein-4.