Table 4.
Odds for hypertension among Inuit§(30–69 years) in Greenland vs. quintiles of whole blood mercury. The analyses are adjusted for confoundersab
| |
Hypertension (1 = hypertension, 0 = no hypertension)c |
|
|---|---|---|
| Whole blood mercury (μg/L) | Odds ratio (95% CI) | Pd (Pe) |
|
Men |
|
|
| Quintile 1 (range: 0.4-8.7) |
1 |
(0.22) |
| Quintile 2 (range: 8.8-17.0) |
1.04 (0.62-1.73) |
0.88 |
| Quintile 3 (range: 17.3-26.1) |
0.65 (0.37-1.15) |
0.14 |
| Quintile 4 (range: 27.0-49.0) |
0.84 (0.45-1.57) |
0.59 |
| Quintile 5 (range: 50.0-280.0) |
0.53 (0.26-1.10) |
0.09 |
|
Women |
|
|
| Quintile 1 (range: 0.05-6.4) |
1 |
(0.60) |
| Quintile 2 (range: 6.6-12.0) |
1.29 (0.77-2.18) |
0.34 |
| Quintile 3 (range: 12.2-20.1) |
1.09 (0.63-1.89) |
0,75 |
| Quintile 4 (range: 21.0-35.0) |
1.51 (0.85-2.69) |
0.16 |
| Quintile 5 (range: 36.0-170.0) | 1.39 (0.72-2.70) | 0.33 |
§ Only participants with four Greenlandic grandparents.
a Confounders: age, smoking habits, blood selenium, ratio of n-3/n-6 fatty acids, waist circumference.
b The models were based on 663 men and 889 women (with non-missing values for all included variables).
c Hypertension was defined as BP ≥ 140/90 mmHg or usage of anti-hypertensive drugs.
d P-value of a “pairwise” comparison with the first quintile of whole blood mercury.
e P-value of a Wald test for the overall effect of whole blood mercury on hypertension.