Table 2.
Summary estimates of diagnostic accuracy from autopsy studies, according to imaging finding and method
| Imaging finding | Number of studies | Sample size | Sensitivity (95% CI) | tau2 for sensitivity | Specificity (95% CI) | tau2 for specificity | Positive likelihood ratio (95% CI) | Negative likelihood ratio (95% CI) | DOR (95% CI) |
|---|---|---|---|---|---|---|---|---|---|
| CT | |||||||||
| White matter hyperintensities |
2 |
84 |
73 (58, 84) |
0 |
63 (46, 77) |
0 |
1.96 (1.23, 3.12) |
0.43 (0.25, 0.75) |
4.5 (1.70, 12) |
| Global assessment |
1 |
32 |
18 (6, 41) |
— |
80 (55, 93) |
— |
0.88 (0.21, 3.73) |
1.03 (0.74, 1.44) |
0.9 (0.20, 4.50) |
| Periventricular hyperintensities |
3 |
31 |
85 (43, 98) |
1.95 |
50 (11, 89) |
2.12 |
1.70 (0.58, 5.05) |
0.30 (0.04, 2.18) |
5.6 (0.32, 100) |
| Lacunar infarcts |
1 |
96 |
12 (4, 29) |
— |
100 (57, 100) |
— |
1.40 (0.08, 23.74) |
0.96 (0.73, 1.27) |
∞ (0.14, ∞) |
| Non-lacunar infarcts |
2 |
79 |
70 (56, 81) |
0 |
93 (80, 99) |
0 |
12.75 (3.28, 49.60) |
0.31 (0.20,0.48) |
41 (8.20, 196) |
| General infarcts |
2 |
123 |
41 (5, 89) |
2.8 |
78 (32, 96) |
1.7 |
1.82 (0.22,15.20) |
0.76 (0.25,2.30) |
2.4 (0.10, 57) |
| MRI | |||||||||
| White matter hyperintensities | 1 | 43 | 79 (52, 92) | — | 28 (15, 46) | — | 1.09 (0.76, 1.55) | 0.78 (0.24, 2.49) | 1.4 (0.33, 5.80) |