Figure 2. Competitive indices (CI) of various Salmonella mutants vs. the parental Salmonella purA ssaGH strain in infected spleen (open circles) and liver (filled circles).

Data are shown for individual mice at day seven post infection. A competitive index of 1 indicates equal colonization capabilities of mutant and parental strains. Statistical significance was determined by t-test of log-transformed data. Spleen colonization of mutants ppk, recA, trxA, ubiC, and fadD fadK was significantly lower compared to the parental strain (P<0.05). Liver colonization of mutants ppk, recA, and fadD fadK was significantly lower compared to the parental strain (P<0.05).