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. 2012 Jul 24;7(7):e41611. doi: 10.1371/journal.pone.0041611

Figure 1. Fra-1 Δ/Δ mice display greater pulmonary inflammatory responses at 7-day post-bleomycin administration.

Figure 1

Mice (n = 8 in each genotype) were intratracheally administered with bleomycin. Left lungs were fixed for histology (n = 4) or used for mRNA analysis (n = 4). Right lobes (n = 8) were used for BAL and protein analysis. Representative results of two different experiments are shown. Samples obatined from mice treated with PBS were from Figure 3 (see below). A: Representative images of H&E stained lung tissue sections of bleomycin-treated Fra-1+/+ and Fra-1 Δ/Δ mice (n = 4). B: Assessment of lung inflammatory cell profiles in the BAL fluid of both genotypes (n = 5). C: Pro-inflammatory cytokines and chemokines gene expression after treatment with bleomycin (n = 4).∗p<0.05, PBS vs bleomycin; †p<0.05, Fra-1 Δ/Δ vs Fra-1+/+ mice. a and b images shown at 4× magnification, while a1 and b1 are boxed areas of a and b, respectively, but shown at x20.