Table 4. Solicited adverse events reported 24 hours following PZQ administration (n = 93).

		Total no. of reports			Reports graded as severe
Organ class	Symptoms	40 mg/kg	75 mg/kg	p *	40 mg/kg	75 mg/kg	p *
		(n = 40)	(n = 39)		(n = 40)	(n = 39)
Systemic	Allergic reaction	1	0	0.32	0	0
	Fever	0	2	0.15	0	0
	Headache	27	31	0.23	0	0
	Anxiety	1	2	0.54	0	0
	Fatigue	24	28	0.27	0	0
	Vertigo/dizziness	20	23	0.42	0	1	0.31
Gastro-intestinal	Nausea	9	12	0.41	0	0
	Vomiting	5	11	0.08	0	2	0.15
	Diarrhea	7	5	0.56	0	0
	Constipation	2	0	0.16	0	0
	Abdominal pain	23	27	0.28	0	0
Cardiovascular	Palpitations	4	6	0.47	0	0
	Hypotension	1	7	0.02	0	0
Respiratory	Cough	1	1	0.99	0	0
	Bronchospasm	1	1	0.99	0	0
	Dyspnea	1	1	0.99	0	0

*: according to exact χ² test.

The two study groups were 40 mg/kg vs. 75 mg/kg divided into 2 doses of 50 mg/kg+25 mg/kg, 4 hours apart.