Table 3. Multivariate analysis results for OS.

			95% CI
Variable	p-value	HR	Lower	Upper	n
SLC6A4-rs12150214 (CG+CC vs GG)	.005	1.572	1.142	2.164	259
Age	<.001	1.049	1.034	1.064
Grade (poorly diff./undiff. vs well/moderately diff.)	<.001	2.372	1.566	3.592
Stage	<.001
Stage (II vs I)	.715	1.103	.651	1.87
Stage (IIIvs I)	.001	2.410	1.419	4.093
Stage (IV vs I)	<.001	11.083	6.267	19.603
MSI status (MSI-H vs MSS/MSI-L)	.002	.357	.186	.686

Only those variables with a p<0.05 in the univariate analysis are included in the multivariate analysis. Significant results are shown in bold. CI: confidence interval, diff: differentiated, HR: hazards ratio, MSI-H: microsatellite instability-high, MSI-L: microsatellite instability-low, MSS: microsatellite stable, n: number of samples included into the analysis, vs: versus. Number of events for OS is 162.