Table 5. Multivariate analysis results for the combined genotypes of three SNPs within the SLC6A4 gene (OS).

			95% CI
Variable	p-value	HR	Lower	Upper	n
SLC6A4 variants (+ vs -)	.002	1.631	1.190	2.236	257
Age	<.001	1.049	1.034	1.065
Grade (poorly diff./undiff. vs well/moderately diff.)	<.001	2.364	1.556	3.589
Stage	<.001
Stage (II vs I)	.698	1.111	.654	1.886
Stage (IIIvs I)	.001	2.476	1.456	4.211
Stage (IV vs I)	<.001	11.244	6.335	19.957
MSI status (MSI-H vs MSS/MSI-L)	.001	.331	.172	.640

Multivariate analysis results for overall survival. (+): patients with at least one minor (variant) allele in any of the three SLC6A4 SNPs, (−): patients who did not have the variant allele in any of the three SLC6A4 SNPs, OS: overall survival.