Figure 2. Activity of vancomycin and nafcillin alone and in combination in the PK/PD model against hVISA strains where the concentration of nafcillin was below the MIC of the respective organism for 100% of the dosing interval.

Graphs shown are of isolate R5253 (Nafcillin MIC = 16 µg/mL) (A), R1915 (Nafcillin MIC = 64 µg/mL) (B), R2729 (Nafcillin MIC = 128 µg/mL) (C), and R3003 (Nafcillin MIC = 256 µg/mL) (D). Data are presented as a graph of the mean bacteria remaining vs. time with error bars at the sampling points representing 1 standard deviation from the mean. GC = Growth Control, NAF = Nafcillin, VAN = Vancomycin.