Figure 6. Effect of a p38 MAP kinase inhibitor on cytokine (A–C), chemokine (D,E) and amphiregulin (F) mRNA expression in high pressure ventilated BALB/c mice.

All lungs were subjected to HPV. Right lungs were harvested after 240 min of ventilation and perfusion and probed by RT-qPCR for Il6 (A), Il1b (B), Tnf (C), Cxcl1 (D), Cxcl2 (E) and Areg (E). LPV, vehicle (DMSO); HPV, SB203580. Data are mean + SEM with n = 6 per study group. (*P<0.05; **P<0.01; ***P<0.001).