Table 3. Haematologic effects of T. b. rhodesiense KETRI2537 infection and treatment with DB844 in vervet monkeys.
| Parameters | Days post infection (days post last drug dose) | |||||
| 0 | 27 | 41 (0) | 48 (7) | 69 (28) | 104 (63) | |
| RBC (×106/µl) | 5.8±0.2 | 4.2±0.2, p<0.0001 | 4.8±0.3, p<0.0001 | 4.9±0.2, p<0.004 | 5.5±0.2, p = 0.55 | 6.1±0.3 p = 0.02 |
| Hemoglobin (g/dl) | 13.4±0.6 | 9.1±0.6, p<0.0001 | 11.2±0.7, p<0.0001 | 11.5±0.6, p<0.0001 | 12.8±0.5, p = 0.15 | 14.1±0.8, p = 0.11 |
| Haematocrit % | 43.9±2.0 | 29.8±1.7, p<0.0001 | 31.6±1.6, p<0.0001 | 31.8±1.6, p<0.0001 | 43.8±1.6, p = 0.91 | 46.7±2.7, p = 0.91 |
| Mean corpuscular volume (fl) | 78.2±1.5 | 70.8±0.8, p<0.0001 | 65.3±0.9, p = 0.0001 | 64.8±0.9, p = 0.0001 | 79.8±1.4, p = 0.11 | 77.0±1.5, p = 0.21 |
| Mean corpuscular haemoglobin (g/dl) | 23.9±0.4 | 21.6±0.3, p<0.0001 | 23.0±0.3 p<0.008 | 23.3±0.4 p = 0.07 | 23.4±0.6, p = 0.13 | 23.3±0.5 p = 0.21 |
| Platelet counts (×103/µl) | 346.5±13.1 | 183.5±24.6 p = 0.002 | 406.5±22.5 p = 0.05 | 390.7±32.4, p = 0.11 | 332.2±11.9, p = 0.78 | 294.3±17.4 p = 0.55 |
| WBC counts (×103/µl) | 5.8±0.5 | 3.0±0.4, p = 0.003 | 7.1±1.0, p = 0.12 | 5.6±1.2, p = 0.9 | 5.9±0.8, p = 0.8 | 5.1±0.1, p = 0.4 |
Key: RBC = red blood cells; WBC = White blood cells; g/dl = grams/decilitre; fl = femtolitres; p-values<0.05 indicate values that were significantly different from pre-infection baseline (day 0) values (Repeated measures Anova with Fishers PLSD post hoc test); Monkey were treated with DB844 at 6 mg/kg×14 days, from 28–41 days post infection.