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. 2012 Jul 24;6(7):e1734. doi: 10.1371/journal.pntd.0001734

Table 3. Haematologic effects of T. b. rhodesiense KETRI2537 infection and treatment with DB844 in vervet monkeys.

Parameters Days post infection (days post last drug dose)
0 27 41 (0) 48 (7) 69 (28) 104 (63)
RBC (×106/µl) 5.8±0.2 4.2±0.2, p<0.0001 4.8±0.3, p<0.0001 4.9±0.2, p<0.004 5.5±0.2, p = 0.55 6.1±0.3 p = 0.02
Hemoglobin (g/dl) 13.4±0.6 9.1±0.6, p<0.0001 11.2±0.7, p<0.0001 11.5±0.6, p<0.0001 12.8±0.5, p = 0.15 14.1±0.8, p = 0.11
Haematocrit % 43.9±2.0 29.8±1.7, p<0.0001 31.6±1.6, p<0.0001 31.8±1.6, p<0.0001 43.8±1.6, p = 0.91 46.7±2.7, p = 0.91
Mean corpuscular volume (fl) 78.2±1.5 70.8±0.8, p<0.0001 65.3±0.9, p = 0.0001 64.8±0.9, p = 0.0001 79.8±1.4, p = 0.11 77.0±1.5, p = 0.21
Mean corpuscular haemoglobin (g/dl) 23.9±0.4 21.6±0.3, p<0.0001 23.0±0.3 p<0.008 23.3±0.4 p = 0.07 23.4±0.6, p = 0.13 23.3±0.5 p = 0.21
Platelet counts (×103/µl) 346.5±13.1 183.5±24.6 p = 0.002 406.5±22.5 p = 0.05 390.7±32.4, p = 0.11 332.2±11.9, p = 0.78 294.3±17.4 p = 0.55
WBC counts (×103/µl) 5.8±0.5 3.0±0.4, p = 0.003 7.1±1.0, p = 0.12 5.6±1.2, p = 0.9 5.9±0.8, p = 0.8 5.1±0.1, p = 0.4

Key: RBC = red blood cells; WBC = White blood cells; g/dl = grams/decilitre; fl = femtolitres; p-values<0.05 indicate values that were significantly different from pre-infection baseline (day 0) values (Repeated measures Anova with Fishers PLSD post hoc test); Monkey were treated with DB844 at 6 mg/kg×14 days, from 28–41 days post infection.