Figure 10.
Colony Forming Units (CFU) of S. aureus recovered from ‘full-thickness’ dermal wounds (in normal wild-type mice) inoculated with 2.1 × 105 CFU/cm2 of S. aureus (illustrated by horizontal line) and treated for 3 days with either Biobrane functionalized with PEMs of (PAH/PAA)10(PS-microspheres)(CX/PAA)80, or unmodified Biobrane (p<0.05, n=10 mice per group, Mann-Whitney U test). Data represent the mean ± SEM from one representative experiment that was repeated three times. Results show that CX/PEMs resulted in 3 log10 reduction in the wound microbial burden under the Biobrane.