Skip to main content
. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Prog Neurobiol. 2012 May 20;98(2):166–175. doi: 10.1016/j.pneurobio.2012.05.006

Figure 3. γSSRF p120ctn recruits cadherins to γ-secretase by binding PS1-CTF.

Figure 3

Catenin protein p120 (p120ctn) known to bind the juxtamembrane region of cadherins (glycine repeat GGG) also binds to the 330–360 amino acid sequence of γ-secretase component PS1-CTF thus recruiting cadherins to γ-secretase complexes for processing (Kouchi et al., 2009). For better clarity, the other core components of γ-secretase are not shown. The cadherin/catenin junction complex binds the actin cytoskeleton via α-catenin. Thus the PS/γ-secretase complex may affect functions of the cellular cytoskeleton (see also Marambaud et al., 2002).