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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Gastroenterology. 2012 Apr 19;143(2):418–428. doi: 10.1053/j.gastro.2012.04.017

Figure 2. Environmental influences on the responsiveness and Vβ-usage of iNKT cells.

Figure 2

(A-C) C57BL/6 animals, purchased from either Taconic Farms (Tac) or Jackson Laboratory (Jax), were either analyzed within one week after delivery (top panels). Or alternatively, new-born offspring from Tac or Jax mice were co-housed from 2–5 days after birth until analysis 8–10 weeks later (lower panels). Relative frequency of iNKT cells (A) and their Vβ7-usage (B) in indicated organs is shown. Production of indicated cytokines by splenic iNKT cells 90min after i.v. injection of αGalCer was analyzed by intracellular staining (C). Representative data from four (top panels) or three (lower panels) independent experiments are shown. (D, E) Frequency of CD127+CD4− iNKT cells in indicated organs (D) or from SI-LPL (E) from indicated mice. Representative data from three independent experiments are shown.