TABLE 1.
Patient characteristics (unadjusted)
| Variable | IC (n = 36) | IS (n = 40) | P | |
|---|---|---|---|---|
| Age, y, median (range) | 58 (33–74) | 68 (48–81) | 0.0005 | |
| Sex, M/F | 30/6 | 35/5 | 0.75 | |
| Histology, Sq/Ad/AdSq/LC | 17/17/1/1 | 22/15/1/2 | 0.80 | |
| Performance status, 0/1 | 26/10 | 31/9 | 0.61 | |
| Period of treatment, 1997–2003/2004–2009 | 14/22 | 23/17 | 0.10 | |
| c stage | T3 N0 | 5 | 18 | <0.001 |
| IIB | T3 N1/N2 | 3/7 | 11/4 | |
| IIIA | T4 N0/N1 | 3/5 | 5/2 | |
| IIIB | T3 N3 | 4 | 0 | |
| T4 N2 | 9 | 0 | ||
| Involved structures | ||||
| cT3 | Chest wall | 12 | 28a | |
| Parietal pleura | 5 | 12 | ||
| Rib or muscle | 7 | 16 | ||
| Diaphragm | 0 | 3a | ||
| Pericardium | 1 | 4a | ||
| Mediastinal pleura | 3 | 1 | ||
| <2 cm carina | 3 | 1 | ||
| cT4 | Atrium | 1 | 0 | |
| Great vessel | 13a | 7 | ||
| Esophagus | 2a | 0 | ||
| Vertebral body | 1a | 0 | ||
| Carina | 2 | 0 | ||
| Superior sulcus | 4 | 1 | ||
IC induction chemoradiotherapy, IS initial surgery, Sq squamous cell carcinoma, Ad adenocarcinoma, AdSq adenosquamous carcinoma, LC large cell carcinoma
a Multiple structures were involved: chest wall with diaphragm (n = 1), with pericardium (n = 2), diaphragm with pericardium (n = 1), great vessel with esophagus (n = 1), with vertebral body (n = 1)