Table 3.
Infiltration of mononuclear and polymorphonuclear cells in the gastric antral and body mucosa of Mongolian gerbils infected with wild-type Helicobacter pylori or the oipA knockout strain
Period | Antrum
|
Body
|
||||
---|---|---|---|---|---|---|
Uninfected control | Wild-type | oipA mutant | Uninfected control | Wild-type | oipA mutant | |
MNC (months) | ||||||
0 | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) |
1 | 0 (0–0) | 1 (0–3) | 0 (0–0) | 0 (0–0) | 0 (0–1) | 0 (0–0) |
3 | 0 (0–0) | 4 (0–5)*,**,# | 3 (0–4)*,** | 0 (0–0) | 2 (0–4)*,**,# | 0 (0–1) |
6 | 0 (0–0) | 5 (4–5)*,** | NE | 0 (0–0) | 3 (3–4)*,**,*** | NE |
12 | 0 (0–0) | 4 (2–4)*,** | NE | 0 (0–0) | 4 (2–4)*,**,*** | NE |
PMN (months) | ||||||
0 | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) |
1 | 0 (0–0) | 0 (0–2) | 0 (0–0) | 0 (0–0) | 0 (0–1) | 0 (0–0) |
3 | 0 (0–0) | 3 (0–4)*,**,# | 1 (0–2) | 0 (0–0) | 1 (0–3)*,**,# | 0 (0–0) |
6 | 0 (0–0) | 3 (2–4)*,** | NE | 0 (0–0) | 2 (1–3)*,** | NE |
12 | 0 (0–0) | 3 (0–3)*,** | NE | 0 (0–0) | 2 (0–3)*,** | NE |
MNC and PMN infiltration levels are expressed as medians (ranges)
MNC mononuclear cells, PMN polymorphonuclear cells, NE not examined
P <0.05 compared with 0 month
P <0.05 compared with the wild-type infected group at 1 month
P <0.05 compared with the wild-type infected group at 3 months
P <0.05 compared with the oipA mutant-infected group at the same time point after infection