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ABT-510 and ABT-898 treatment decreased PCNA expression induced by DES. Pituitaries of the different experimental groups were homogenized and protein expression was analyzed by Western blot. PCNA expression was normalized to β-actin. PCNA expression was higher in the DES control group compared with the diestrus group. *, P = 0.0002. Both ABT-510 and ABT-898 significantly reduced the PCNA protein levels. #, P = 0.03; &, P = 0.0002. Representative bands are shown (n = 6, 10, 11, and 10).
