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. 2012 Jun 14;153(8):3861–3871. doi: 10.1210/en.2012-1007

Fig. 5.

Fig. 5.

Latent TGF-β binding protein mRNA are expressed in normal and tumoral pituitaries and differentially controlled by DES. LTBP1, LTBP3, and LTBP4 are expressed in normal pituitaries and in prolactinomas induced by DES. A, Pituitary LTBP1 mRNA was decreased after 4 wk DES pellet implantation in female rats. *, P = 0.009 (n = 4). B, LTBP3 mRNA expression was not altered by DES. C, LTBP4 mRNA was significantly reduced by DES. *, P = 0.01 (n = 4). D and E, Treatment with ABT-510 and ABT-898 did not restore either LTBP1 (D, *, P < 0.001, n = 4) or LTBP4 (E, *, P < 0.001, n = 4) expression in DES-induced prolactinomas.