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. 2012 Jun 14;153(8):3861–3871. doi: 10.1210/en.2012-1007

Fig. 6.

Fig. 6.

Short-term effect of ABT-510 in pituitary TGF-β1 activation and serum PRL. A, Pituitary active TGF-β1 was evaluated by ELISA after 30 min, 2 h, or 24 h of a 100 mg/kg ABT-510 single injection in control female rats in diestrus. ABT-510 enhanced active TGF-β1 content in pituitary glands after 30 min and 2 h. *, P = 0.04; #, P = 0.02 (n = 10, 4, 8, and 6). B, Serum PRL levels measured by RIA were reduced after 30 min and 2 h of ABT-510 treatment. *, P = 0.006; #, P = 0.001 (n = 10, 4, 8, and 6). C, Total TGF-β1 content was not modified after 24 h of an ABT-510 injection in control rats in diestrus. D, Pituitary active TGF-β1 was also induced by ABT-510 after 2 h in a group of 4-wk DES-treated rats. *, P = 0.036 (n = 5). E, Serum PRL values were reduced by ABT-510 after 2 h in DES rats. *, P = 0.02 (n = 5).