Table 1.
Differentially expressed pituitary genes in DES-treated ACI rats that are also aberrantly expressed in human prolactinomas
| Gene symbol | Gene title | ACI |
|
|---|---|---|---|
| Fold | P value | ||
| Gal | Galanin prepropeptide | 214.0 | 1.16E-04 |
| Vip | Vasoactive intestinal peptide | 28.7 | 2.36E-03 |
| Cfp | Complement factor properdin | 12.8 | 6.13E-03 |
| Lpl | Lipoprotein lipase | 12.8 | 1.63E-03 |
| Nupr1 | Nuclear protein 1 | 10.7 | 2.70E-03 |
| Nov | Nephroblastoma overexpressed gene | 8.0 | 1.17E-03 |
| Pgr | Progesterone receptor | 7.9 | 2.41E-04 |
| Sstr3 | Somatostatin receptor 3 | 7.5 | 1.97E-04 |
| Mki67 | Antigen identified by monoclonal antibody Ki-67 | 7.0 | 2.25E-03 |
| Cdc2 | Cell division cycle 2, G1 to S and G2 to M | 6.5 | 2.52E-03 |
| Tnf | TNF (TNF superfamily, member 2) | 6.4 | 4.74E-03 |
| Bag1 | BCL2-associated athanogene | 5.8 | 1.74E-04 |
| Lgals3 | Lectin, galactoside-binding, soluble, 3 | 5.4 | 3.73E-04 |
| Myc | Myelocytomatosis oncogene | 4.9 | 1.82E-03 |
| Pttg1 | Pituitary tumor-transforming 1 | 4.8 | 2.31E-03 |
| Ntrk2 | Neurotrophic tyrosine kinase, receptor, type 2 | 4.7 | 1.66E-04 |
| Mpg | N-methylpurine-DNA glycosylase | 4.3 | 3.31E-04 |
| Egfr | Epidermal growth factor receptor | 3.7 | 8.57E-03 |
| Egf | Epidermal growth factor | 3.4 | 4.20E-04 |
| Ccnb1 | Cyclin B1 | 3.3 | 6.32E-04 |
| Igfbp3 | IGF binding protein 3 | 3.2 | 5.05E-03 |
| Sla | Src-like adaptor | 3.0 | 1.96E-04 |
| Ccnd3 | Cyclin D3 | 2.9 | 2.58E-03 |
| Igf1 | IGF-I | 2.9 | 7.64E-03 |
| Cope | Coatomer protein complex, subunit-ϵ | 2.7 | 3.09E-03 |
| Aga | Aspartylglucosaminidase | 2.5 | 9.19E-04 |
| Tgfb3 | TGFβ3 | 2.4 | 7.01E-04 |
| Bid | BH3 interacting domain death agonist | 2.3 | 8.34E-04 |
| Cs | Citrate synthase | 2.2 | 4.66E-03 |
| Pts | 6-Pyruvoyl-tetrahydropterin synthase | 2.1 | 9.92E-03 |
| E2f1 | E2F transcription factor 1 | 2.0 | 8.57E-03 |
| Guk1 | Guanylate kinase 1 | 1.9 | 1.97E-03 |
| Poll | Polymerase (DNA directed), λ | 1.9 | 3.63E-03 |
| Grb2 | Growth factor receptor bound protein 2 | 1.6 | 2.97E-03 |
| Chgb | Chromogranin B | 1.5 | 8.98E-03 |
| Prkar1a | Protein kinase, cAMP dependent regulatory, type I, α | 1.5 | 1.94E-03 |
| Preb | Prolactin regulatory element binding | 1.4 | 8.11E-03 |
| Cdkn1b | Cyclin-dependent kinase inhibitor 1B | 1.4 | 1.18E-03 |
| D2R | Dopamine D2 receptor | 1.4 | 4.53E-03 |
| Ncl | Nucleolin | 1.4 | 6.79E-03 |
| Gpi | Glucose phosphate isomerase | 1.4 | 6.39E-03 |
| Ctnna1 | Catenin (cadherin associated protein), α1 | −1.5 | 3.54E-03 |
| Pou1f1 | POU class 1 homeobox 1 | −1.5 | 4.80E-03 |
| Slc20a1 | Solute carrier family 20 (phosphate transporter), member 1 | −1.7 | 1.40E-03 |
| Pitx1 | Paired-like homeodomain 1 | −1.8 | 9.03E-03 |
| Dst | Dystonin | −1.9 | 3.56E-03 |
| Jup | Junction plakoglobin | −2.1 | 6.92E-03 |
| Cp | Ceruloplasmin | −2.3 | 4.02E-03 |
| Ghr | GH receptor | −2.7 | 3.19E-03 |
| Gstm1 | Glutathione S-transferase μ 1 | −2.7 | 5.06E-03 |
| Chga | Chromogranin A | −2.9 | 1.36E-03 |
| Sms | Spermine synthase | −3.1 | 1.94E-03 |
| Prlr | Prolactin receptor | −3.7 | 8.18E-03 |
| Nrg1 | Neuregulin 1 | −5.0 | 7.01E-04 |
| Rab3b | RAB3B, member RAS oncogene family | −18.2 | 6.35E-04 |
| Ret | Ret protooncogene | −21.3 | 3.75E-03 |
| Spp1 | Secreted phosphoprotein 1 | −44.5 | 1.56E-03 |