Table 2.
Representative pituitary genes concordantly expressed in DES-induced ACI rat and human prolactinomas
| Gene symbol | Gene title | ACI rat |
Human |
||
|---|---|---|---|---|---|
| Fold | P value | Fold | P value | ||
| Cgref1 | Cell growth regulator with EF hand domain 1 | 211.3 | 1.9E-05 | 1.3 | 3.2E-02 |
| Plaur | Plasminogen activator, urokinase receptor | 49.0 | 1.2E-04 | 1.3 | 8.4E-03 |
| Ptprc | Protein tyrosine phosphatase, receptor type, C | 13.3 | 8.3E-03 | 1.2 | 1.4E-02 |
| Spc25 | SPC25, NDC80 kinetochore complex component, homolog (Saccharomyces cerevisiae) | 5.6 | 1.1E-03 | 1.1 | 6.1E-03 |
| Myc | Myelocytomatosis oncogene | 4.9 | 1.8E-03 | 1.4 | 1.8E-02 |
| Ccng1 | Cyclin G1 | 4.3 | 3.0E-04 | 1.4 | 2.5E-02 |
| Scamp5 | Secretory carrier membrane protein 5 | 3.5 | 7.9E-03 | 1.4 | 3.5E-02 |
| Ptprn | Protein tyrosine phosphatase, receptor type, N | 3.2 | 4.4E-04 | 1.8 | 1.4E-03 |
| Faim3 | Fas apoptotic inhibitory molecule 3 | 3.0 | 3.9E-03 | 1.3 | 8.1E-03 |
| Igf1 | IGF-I | 2.9 | 7.6E-03 | 1.2 | 1.2E-02 |
| Ern1 | Endoplasmic reticulum to nucleus signaling 1 | 2.8 | 1.8E-04 | 1.1 | 2.2E-02 |
| Eif4ebp1 | Eukaryotic translation initiation factor 4E binding protein 1 | 2.5 | 1.8E-03 | 1.2 | 3.7E-02 |
| Spink5 | Serine peptidase inhibitor, Kazal type 5 | 2.4 | 6.0E-03 | 1.1 | 1.7E-02 |
| Atf6 | Activating transcription factor 6 | 2.3 | 2.3E-03 | 1.2 | 3.3E-02 |
| Atp2a3 | ATPase, Ca2+ transporting, ubiquitous | 2.2 | 9.9E-03 | 1.1 | 2.2E-02 |
| Polr2e | Polymerase (RNA) II (DNA directed) polypeptide E, 25 kDa | 2.1 | 3.0E-04 | 1.3 | 3.5E-02 |
| Rala | V-ral simian leukemia viral oncogene homolog A (ras related) | 2.1 | 4.2E-04 | 1.4 | 8.5E-03 |
| E2f1 | E2F transcription factor 1 | 2.0 | 8.6E-03 | 1.2 | 1.3E-02 |
| Akt2 | V-akt murine thymoma viral oncogene homolog 2 | 2.0 | 7.9E-03 | 1.2 | 3.4E-02 |
| Atf1 | Activating transcription factor 1 | 2.0 | 4.8E-03 | 1.3 | 5.3E-03 |
| Mcm6 | Minichromosome maintenance complex component 6 | 1.9 | 1.9E-03 | 1.4 | 4.9E-02 |
| Npr2 | Natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) | 1.8 | 4.3E-03 | 1.2 | 2.3E-02 |
| Dnajb5 | DnaJ (Hsp40) homolog, subfamily B, member 5 | 1.7 | 6.0E-03 | 1.8 | 1.3E-02 |
| Fntb | Farnesyltransferase, CAAX box, β | 1.7 | 3.3E-03 | 1.2 | 3.8E-02 |
| Bcr | Breakpoint cluster region | −1.4 | 5.0E-03 | −1.3 | 2.4E-02 |
| Add1 | Dducing 1 (α) | −1.6 | 1.8E-03 | −1.1 | 2.4E-03 |
| Hes1 | Hairy and enhancer of split 1 (Drosophila) | −1.8 | 3.7E-03 | −1.6 | 4.3E-03 |
| Ddit4 | DNA damage-inducible transcript 4 | −1.9 | 3.0E-03 | −3.4 | 6.6E-03 |
| Map3k4 | MAPK kinase kinase 4 | −2.0 | 6.4E-03 | −1.4 | 9.6E-03 |
| Plch2 | Phospholipase C, η2 | −2.0 | 8.4E-03 | −1.5 | 4.1E-03 |
| Hspa2 | Heat shock protein 2 | −2.0 | 5.8E-03 | −2.8 | 4.4E-06 |
| Mdm1 | Mdm1 nuclear protein homolog (mouse) | −2.2 | 3.2E-03 | −1.8 | 1.1E-02 |
| Sox2 | SRY (sex determining region Y)-box 2 | −2.3 | 9.0E-03 | −1.3 | 1.1E-02 |
| Ghrhr | GHRH receptor | −2.3 | 7.0E-03 | −1.8 | 2.0E-02 |
| Prkci | Protein kinase C, iota | −2.4 | 6.7E-03 | −1.7 | 4.8E-02 |
| Cdh2 | Cadherin 2 | −2.5 | 3.2E-03 | −1.9 | 7.1E-03 |
| Rorb | RAR-related orphan receptor B | −3.0 | 8.5E-03 | −1.2 | 1.1E-02 |
| Igfbp5 | IGF binding protein 5 | −3.3 | 2.6E-03 | −10.8 | 1.4E-03 |
| Gpc3 | Glypican 3 | −3.8 | 2.6E-03 | −12.0 | 3.0E-05 |
| Lpin1 | Lipin 1 | −4.3 | 1.7E-04 | −1.9 | 2.0E-02 |
| Dlk1 | δ-Like 1 homolog (Drosophila) | −4.4 | 1.3E-03 | −18.9 | 1.1E-04 |
| Cdh1 | Cadherin 1 | −4.7 | 5.5E-03 | −2.6 | 7.3E-04 |
| Dhcr24 | 24-Dehydrocholesterol reductase | −5.1 | 5.8E-04 | −1.3 | 1.3E-02 |
| Wfdc2 | WAP four-disulfide core domain 2 | −5.3 | 5.1E-04 | −2.4 | 1.6E-06 |
| Itpr1 | Inositol 1,4,5-triphosphate receptor, type 1 | −6.4 | 2.6E-04 | −2.2 | 3.6E-03 |
| Stmn2 | Stathmin-like 2 | −6.6 | 1.7E-04 | −2.2 | 4.4E-06 |
| Fam107a | Family with sequence similarity 107, member A | −8.2 | 1.4E-03 | −1.7 | 2.4E-03 |
| Tmem30b | Transmembrane protein 30B | −8.5 | 1.9E-03 | −1.7 | 5.7E-03 |
| Cebpd | CCAAT/enhancer binding protein (C/EBP), δ | −9.8 | 1.4E-03 | −4.3 | 4.9E-05 |
| Nnat | Neuronatin | −12.8 | 6.8E-04 | −9.9 | 2.8E-04 |
| Efemp1 | EGF-containing fibulin-like extracellular matrix protein 1 | −52.5 | 8.9E-03 | −1.4 | 1.3E-02 |