Figure 3.
Genomic organization of 14q32 microRNA (miRNA) clusters neighboring the DLK1-DIO3 imprinted domain. DLK1, RTL1 and DIO3 (blue rectangles) are paternally expressed genes. The maternally expressed non-coding RNA genes (pink) include maternally expressed gene 3 (MEG3), anti-RTL1 (encodes the smaller miRNA cluster A), maternally expressed gene 8 (MEG8) (encodes small nucleolar RNA (snoRNA) cluster) and the larger miRNA cluster B. The intergenic germline derived differentially methylated region (IG-DMR) is methylated on the paternal chromosome denoted by the encircled letter m. The 14q32 miRNA clusters are arranged in two segments: each separated by a C/D snoRNA cluster. miRNA in dark green italic font were significantly downregulated in schizophrenia and miRNA in blue exhibited a trend for downregulation in schizophrenia. miRNA in black were expressed but not differentially expressed, and in gray were not expressed. This figure was adapted from Royo and Cavaille64 and Hagan et al.103