Table 2. miRNA significantly downregulated in schizophrenia compared with non-psychiatric controls.
| miRNA ID | Fold change | q-Value | Chromosomal coordinates |
|---|---|---|---|
| hsa-miR-329 | 0.753 | 0 | hsa-miR-329-1 14: 101 493 122–101 493 201 [+] hsa-miR-329-2 14: 101 493 437–101 493 520 [+] |
| hsa-miR-31 | 0.754 | 0 | 9: 21 512 114–21 512 184 [−] |
| hsa-miR-409-3p | 0.757 | 0 | 14: 101 531 637–101 531 715 [+] |
| hsa-miR-224 | 0.762 | 0 | X: 151 127 050–151 127 130 [−] |
| hsa-miR-432 | 0.763 | 0 | 14: 101 350 820–101 350 913 [+] |
| hsa-miR-487b | 0.764 | 0 | 14: 101 512 792–101 512 875 [+] |
| hsa-miR-134 | 0.764 | 0 | 14: 101 521 024–101 521 096 [+] |
| hsa-miR-431 | 0.765 | 0 | 14: 101 347 344–101 347 457 [+] |
| hsa-miR-150* | 0.771 | 0 | 19: 50 004 042–50 004 125 [−] |
| hsa-miR-99b | 0.783 | 0 | 19: 52 195 865–52 195 934 [+] |
| hsa-miR-1275 | 0.798 | 0 | 6: 33 967 749–33 967 828 [−] |
| hsa-miR-335* | 0.799 | 0 | 7: 130 135 952–130 136 045 [+] |
| hsa-miR-200c | 0.813 | 0 | 12: 7 072 862–7 072 929 [+] |
| hsa-miR-486-3p | 0.815 | 0 | 8: 41 517 959–41 518 026 [−] |
| hsa-miR-29b-1* | 0.817 | 0 | 7: 130 562 218–130 562 298 [−] |
| hsa-miR-16-2* | 0.821 | 0 | 3: 160 122 533–160 122 613 [+] |
| hsa-miR-877 | 0.83 | 0 | 6: 30 552 109–30 552 194 [+] |
| hsa-miR-107 | 0.835 | 0 | 10: 91 352 504–91 352 584 [−] |
| hsa-miR-130b* | 0.839 | 0 | 22: 22 007 593–22 007 674 [+] |
| hsa-miR-544 | 0.843 | 0 | 14: 101 514 995–101 515 085 [+] |
| hsa-miR-342-5p | 0.844 | 0 | 14: 100 575 992–100 576 090 [+] |
| hsa-miR-148b | 0.844 | 0 | 12: 54 731 000–54 731 098 [+] |
| hsa-miR-625* | 0.856 | 0 | 14: 65 937 820–65 937 904 [+] |
| hsa-miR-28-3p | 0.858 | 0 | 3: 188 406 569–188 406 654 [+] |
| hsa-miR-576-5p | 0.86 | 0 | 4: 110 409 854–110 409 951 [+] |
| hsa-miR-151-3p | 0.864 | 0 | 8: 141 742 663–141 742 752 [−] |
| hsa-miR-28-5p | 0.869 | 0 | 3: 188 406 569–188 406 654 [+] |
| hsa-miR-664 | 0.871 | 0 | 1: 220 373 880–220 373 961 [−] |
| hsa-miR-128 | 0.874 | 0 | hsa-miR-128-1 2: 136 422 967–136 423 048 [+] hsa-miR-128-2 3: 35 785 968–35 786 051 [+] |
| hsa-miR-584 | 0.879 | 0 | 5: 148 441 876–148 441 972 [−] |
| hsa-miR-574-3p | 0.883 | 0 | 4: 38 869 653–38 869 748 [+] |
| hsa-miR-181a | 0.913 | 0 | hsa-miR-181a-1 1: 198 828 173–198 828 282 [−] hsa-miR-181a-2 9: 127 454 721–127 454 830 [+] |
| hsa-miR-30e* | 0.917 | 0 | 1: 41 220 027–41 220 118 [+] |
| hsa-miR-433 | 0.664 | 1.555 | 14: 101 348 223–101 348 315 [+] |
| hsa-miR-654-5p | 0.73 | 1.555 | 14: 101 506 556–101 506 636 [+] |
| hsa-miR-193b | 0.806 | 1.555 | 16: 14 397 824–14 397 906 [+] |
| hsa-miR-485-3p | 0.816 | 1.555 | 14: 101 521 756–101 521 828 [+] |
| hsa-miR-370 | 0.831 | 1.555 | 14: 101 377 476–101 377 550 [+] |
| hsa-miR-340* | 0.854 | 1.555 | 5: 179 442 303–179 442 397 [−] |
| hsa-miR-1271 | 0.854 | 1.555 | 5: 175 794 949–175 795 034 [+] |
| hsa-miR-151 | 0.855 | 1.555 | 8: 141 742 663–141 742 752 [−] |
| hsa-miR-15b* | 0.86 | 1.555 | 3: 160 122 376–160 122 473 [+] |
| hsa-miR-502-3p, hsa-miR-500* | 0.86 | 1.555 | X: 49 779 206–49 779 291 [+] |
| hsa-miR-27b | 0.905 | 1.555 | 9: 97 847 727–97 847 823 [+] |
| hsa-miR-199a-3p, hsa-miR-199b-3p | 0.922 | 1.555 | hsa-miR-199a-1 19: 10 928 102–10 928 172 [−] hsa-miR-199a-2 1: 172 113 675–172 113 784 [−] hsa-miR-199b 9: 131 007 000–131 007 109 [−] |
| hsa-miR-151-5p | 0.933 | 1.555 | 8: 141 742 663–141 742 752 [−] |
| hsa-miR-146a | 0.95 | 1.555 | 5: 159 912 359–159 912 457 [+] |
| hsa-miR-21 | 0.957 | 1.555 | 17: 57 918 627–57 918 698 [+] |
| hsa-miR-30d | 0.959 | 1.555 | 8: 135 817 119–135 817 188 [−] |
| hsa-miR-127-3p | 0.727 | 2.131 | 14: 101 349 316–101 349 412 [+] |
| hsa-miR-98 | 0.82 | 2.131 | X: 53 583 184–53 583 302 [−] |
| hsa-miR-328 | 0.864 | 2.131 | 16: 67 236 224–67 236 298 [−] |
| hsa-miR-181b | 0.875 | 2.131 | hsa-miR-181b-1 1: 198 828 002–198 828 111 [−] hsa-miR-181b-2 9: 127 455 989–127 456 077 [+] |
| hsa-miR-378 | 0.882 | 2.131 | 5: 149 112 388–149 112 453 [+] |
| hsa-miR-150 | 0.963 | 2.131 | 19: 50 004 042–50 004 125 [−] |
| hsa-miR-323-3p | 0.796 | 2.74 | 14: 101 492 069–101 492 154 [+] |
| hsa-miR-874 | 0.797 | 2.74 | 5: 136 983 261–136 983 338 [−] |
| hsa-miR-330-3p | 0.857 | 2.74 | 19: 46 142 252–46 142 345 [−] |
| hsa-miR-500 | 0.862 | 2.74 | X: 49 773 039–49 773 122 [+] |
| hsa-miR-181a-2* | 0.878 | 2.74 | 9: 127 454 721–127 454 830 [+] |
| hsa-miR-146b-5p | 0.912 | 2.74 | 10: 104 196 269–104 196 341 [+] |
| hsa-let-7b | 0.952 | 2.74 | 22: 46 509 566–46 509 648 [+] |
| hsa-miR-25 | 0.956 | 2.74 | 7: 99 691 183–99 691 266 [−] |
| hsa-miR-92a | 0.957 | 2.74 | hsa-miR-92a-1 13: 92 003 568–92 003 645 [+] hsa-miR-92a-2 X: 133 303 568–133 303 642 [−] |
| hsa-miR-410 | 0.812 | 3.288 | 14: 101 532 249–101 532 328 [+] |
| hsa-miR-221* | 0.815 | 3.288 | X: 45 605 585–45 605 694 [-] |
| hsa-miR-942 | 0.825 | 3.288 | 1: 117 637 265–117 637 350 [+] |
| hsa-miR-664* | 0.845 | 3.288 | 1: 220 373 880–220 373 961 [−] |
| hsa-miR-20b | 0.865 | 3.288 | X: 133 303 839–133 303 907 [−] |
| hsa-miR-628-3p | 0.867 | 3.288 | 15: 55 665 138–55 665 232 [−] |
| hsa-miR-152 | 0.892 | 3.288 | 17: 46 114 527–46 114 613 [−] |
| hsa-let-7d | 0.957 | 3.288 | 9: 96 941 116–96 941 202 [+] |
| hsa-miR-154 | 0.766 | 4.484 | 14: 101 526 092–101 526 175 [+] |
| hsa-miR-337-3p | 0.87 | 4.484 | 14: 101 340 830–101 340 922 [+] |
| hsa-miR-505 | 0.884 | 4.484 | X: 139 006 307–139 006 390 [−] |
| hsa-miR-625 | 0.897 | 4.484 | 14: 65 937 820–65 937 904 [+] |
| hsa-miR-22* | 0.898 | 4.484 | 17: 1 617 197–1 617 281 [−] |
| hsa-let-7g | 0.965 | 4.484 | 3: 52 302 294–52 302 377 [−] |
| hsa-miR-1301 | 0.869 | 4.853 | 2: 25 551 509–25 551 590 [−] |
| hsa-let-7d* | 0.905 | 4.853 | 9: 96 941 116–96 941 202 [+] |
| hsa-miR-766 | 0.93 | 4.853 | X: 11 8780 701–118 780 811 [−] |
| hsa-let-7a | 0.971 | 4.853 | hsa-let-7a-1 9: 96 938 239–96 938 318 [+] hsa-let7a-2 11: 12 2017 230–122 017 301 [−] hsa-let7a-3 22: 46 508 629–46 508 702 [+] |
Abbreviation: miRNA, microRNA.
Differentially expressed miRNA were ranked by significance and then by fold change. miRNA transcribed from the genomic region encompassing 14q32.2–q32.31 were identified with bold font. *Denotes star form of the mature miRNA.