Table 3. Pathways enriched with target genes predicted by a union of miRanda and TargetScan target lists for the 14q32 cluster.
| Category | Term | n | % | P-value | Benjamini |
|---|---|---|---|---|---|
| KEGG_PATHWAY | Pathways in cancer | 108 | 0.3 | <0.000 | <0.000 |
| KEGG_PATHWAY | Axon guidance | 54 | 0.1 | <0.000 | <0.000 |
| KEGG_PATHWAY | Adherens junction | 36 | 0.1 | <0.000 | <0.000 |
| KEGG_PATHWAY | Regulation of actin cytoskeleton | 72 | 0.2 | <0.000 | <0.000 |
| KEGG_PATHWAY | Focal adhesion | 68 | 0.2 | <0.000 | <0.000 |
| KEGG_PATHWAY | Chronic myeloid leukemia | 32 | 0.1 | <0.000 | <0.000 |
| KEGG_PATHWAY | Insulin signaling pathway | 48 | 0.1 | <0.000 | <0.000 |
| KEGG_PATHWAY | Renal cell carcinoma | 30 | 0.1 | <0.000 | <0.000 |
| KEGG_PATHWAY | ErbB signaling pathway | 34 | 0.1 | <0.000 | 0.001 |
| KEGG_PATHWAY | MAPK signaling pathway | 79 | 0.2 | <0.000 | 0.001 |
| KEGG_PATHWAY | Pancreatic cancer | 29 | 0.1 | <0.000 | 0.0016 |
| KEGG_PATHWAY | Ubiquitin-mediated proteolysis | 46 | 0.1 | <0.000 | 0.0018 |
| KEGG_PATHWAY | Wnt signaling pathway | 49 | 0.1 | <0.000 | 0.0024 |
| KEGG_PATHWAY | Prostate cancer | 33 | 0.1 | <0.000 | 0.0023 |
| KEGG_PATHWAY | Long-term potentiation | 27 | 0.1 | <0.000 | 0.0028 |
| KEGG_PATHWAY | Glioma | 25 | 0.1 | <0.000 | 0.0049 |
| KEGG_PATHWAY | Neurotrophin signaling pathway | 41 | 0.1 | <0.000 | 0.0046 |
| KEGG_PATHWAY | Colorectal cancer | 30 | 0.1 | <0.000 | 0.0078 |
| KEGG_PATHWAY | mTOR signaling pathway | 21 | 0.1 | 0.0011 | 0.0110 |
| KEGG_PATHWAY | Endocytosis | 54 | 0.1 | 0.0012 | 0.0110 |
| KEGG_PATHWAY | Melanogenesis | 33 | 0.1 | 0.0015 | 0.0130 |
| KEGG_PATHWAY | Calcium signaling pathway | 50 | 0.1 | 0.0039 | 0.0320 |
| KEGG_PATHWAY | Non-small-cell lung cancer | 20 | 0.1 | 0.0047 | 0.0370 |
| KEGG_PATHWAY | Progesterone-mediated oocyte maturation | 28 | 0.1 | 0.0053 | 0.0400 |
| KEGG_PATHWAY | TGF-β signaling pathway | 28 | 0.1 | 0.0063 | 0.0460 |
| KEGG_PATHWAY | Melanoma | 24 | 0.1 | 0.0064 | 0.0450 |
| KEGG_PATHWAY | T-cell receptor signaling pathway | 33 | 0.1 | 0.0067 | 0.0450 |
| KEGG_PATHWAY | Jak-STAT signaling pathway | 44 | 0.1 | 0.0070 | 0.0450 |
| KEGG_PATHWAY | Dilated cardiomyopathy | 29 | 0.1 | 0.0073 | 0.0460 |
| KEGG_PATHWAY | HCM | 27 | 0.1 | 0.0089 | 0.0540 |
| KEGG_PATHWAY | Oocyte meiosis | 33 | 0.1 | 0.0090 | 0.0530 |
Abbreviations: HCM, hypertrophic cardiomyopathy; KEGG, Kyoto Encyclopedia of Genes and Genomes; MAPK, mitogen-activated protein kinase; mTOR, mammalian target of rapamycin; TGF, tumor growth factor.
Enriched KEGG pathways identified by WebGestalt gene set analysis using predicted target genes. The list was compiled from an union of the miRanda and TargetScan predicted targets of 17 members of the miR-14q32 cluster differentially expressed in schizophrenia. n, number of input genes in pathway (filtered to only show pathways represented by ⩾7 target genes). %, percentage of total target genes analyzed (∼3600 gene IDs) that are represented in this pathway.