Table 1.
Expression and function of Fas and sensitivity to Fas-induced cell death in different B cell populations.
| Cell type | Human | Mouse | |
|---|---|---|---|
| B1 cells | Expression | Negative, CD40 stimulation upregulates Fas expression and induces a biphasic profile (Huck et al., 1998; Kodama et al., 2001) | Negative, LPS stimulation upregulates Fas expression (Mandik et al., 1995) and induces a biphasic profile (Hirose et al., 1997; reviewed in Wang and Watanabe, 1999) |
| Function | Biphasic sensitivity (Kodama et al., 2001) | Hardly susceptible (Masuda et al., 1997), Function in autoantibody production in lpr mice (Watanabe et al., 2002; Qian et al., 2006) biphasic sensitivity (Hirose et al., 1997) | |
| Mantle zone | Expression | Negative, inducible? (Leithauser et al., 1993; Moller et al., 1993; Yoshino et al., 1994; Tsunoda et al., 2000) | No data |
| Function | Participation in autoantibody production (Qian et al., 2006) | No data | |
| Pre, pro, immature | Expression | Weak (Nishiuchi et al., 1996; Nilsson et al., 2000) | Weak, positive (Mandik et al., 1995; Onel et al., 1995) |
| Function | Resistant (Nishiuchi et al., 1996; Nilsson et al., 2000) debated in Lanvin et al. (2003) | Resistant (Mandik et al., 1995; Onel et al., 1995) | |
| Blood | Expression | 5–25% positive (Miyawaki et al., 1992; Daniel and Krammer, 1994), PKW (Daniel and Krammer, 1994; Yoshino et al., 1994), IL2 + aIgM induces (Huck et al., 1998) | Partially positive, LPS induces (Wang et al., 1996) |
| Function | Resistant (Yoshino et al., 1994) sensitive upon upregulation (Daniel and Krammer, 1994) | Resistant (Wang et al., 1996) | |
| Memory | Expression | Low positivity (Liu et al., 1995; Choe et al., 1996; Lagresle et al., 1996) | Low positivity (Tsunoda et al., 2000; Takahashi et al., 2001) |
| Function | Resistant (Liu et al., 1995; Choe et al., 1996; Lagresle et al., 1996; high BCL-2 expression) | Resistant (Tsunoda et al., 2000; Takahashi et al., 2001; high BCL-2 expression) | |
| Plasma cells | Expression | Tonsil: positive (Choe et al., 1996), negative (Moller et al., 1993; Merville et al., 1996) in bone marrow: weakly positive (Nishiuchi et al., 1996) | Weak positivity upon immunization in spleen (Smith et al., 1995) |
| Function | Leukemia or myeloma cells unclear results (Shima et al., 1995; Sampalo et al., 2000) | No data |
For germinal center cells, see the text.