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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Adv Drug Deliv Rev. 2011 Dec 9;64(8):756–762. doi: 10.1016/j.addr.2011.11.009

Fig. 1.

Fig. 1

Strategies to improve TCR activity. Shown are the varieties of different strategies that can be used to potentially improve TCR activity (see text for details). These methods include creating hybrid molecules containing the constant region (CR) from murine TCR chains, as well as adding extra disulfide bonds, and altering amino acids or glycosylation sites within the TCR chains. Mutagenesis of amino acids in the complementarity determining region 3 (CDR3) and knocking down endogenous TCR gene expression using short interfering RNAs (siRNA) can also increase the overall reactivity of the introduced TCR.