Table 1.
TCR gene therapy trials registered in the United States.
Data from: ClinicalTrial.gov 08/04/2011.
| Disease | TCR-target | Lymphodepletion | Gene transfer | ClinicalTrial.gov identifier |
|---|---|---|---|---|
| Melanoma | MART-1 | Y | RTV |
NCT00509288 NCT00910650 |
| Melanoma | gp100 | Y | RTV | NCT00509496 |
| Renal cancer | DR4-TRAIL | Y | RTV | NCT00923390 |
| p53 expressing metastatic cancer | p53 | Y | RTV | NCT00393029 |
| HIV infection | HIV-Gag | N | LTV | NCT00991224 |
| CEA expressing metastatic cancer | CEA | Y | RTV | NCT00923806 |
| NY-ESO-1 expressing metastatic cancer | NYE-ESO-1 | Y | RTV | NCT00670748 |
| MAGE-A3.12 expressing metastatic cancer | MAGE-A3/12 | Y | RTV | NCT01273181 |
| Melanoma | NY-ESO-1/MAGE-A3 | Y | LTV | NCT01350401 |
| Myeloma | MAGE-A3/NY-ESO | N | LTV | NCT01352286 |
Abbreviation: RTV, retrovirus; LTV, lentivirus.